2019

Nosenko MA, Atretkhany KN, Mokhonov VV, Vasilenko EA, Kruglov AA, Tillib SV, Drutskaya MS, Nedospasov SA. Modulation of bioavailability of proinflammatory cytokines produced by myeloid cells. Semin Arthritis Rheum. 2019 Dec;49(3S):S39-S42. doi: 10.1016/j.semarthrit.2019.09.012.

Gogoleva VS, Drutskaya MS, Atretkhany KS. The Role of Microglia in the Homeostasis of the Central Nervous System and Neuroinflammation. Mol Biol (Mosk). 2019 Sep-Oct;53(5):790-798. doi: 10.1134/S0026898419050057.

Gorshkova EA, Zvartsev RV, Drutskaya MS, Gubernatorova EO. Humanized Mouse Models as a Tool to Study Proinflammatory Cytokine Overexpression. Mol Biol (Mosk). 2019 Sep-Oct;53(5):755-773. doi: 10.1134/S0026898419050070.

Nosenko MA, Ambaryan SG, Drutskaya MS. Proinflammatory Cytokines and Skin Wound Healing in Mice. Mol Biol (Mosk). 2019 Sep-Oct;53(5):741-754. doi: 10.1134/S0026898419050136.

Bonnardel J, T’Jonck W, Gaublomme D, Browaeys R, Scott CL, Martens L, Vanneste B, De Prijck S, Nedospasov SA, Kremer A, Van Hamme E, Borghgraef P, Toussaint W, De Bleser P, Mannaerts I, Beschin A, van Grunsven LA, Lambrecht BN, Taghon T, Lippens S, Elewaut D, Saeys Y, Guilliams M. Immunity. Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche. 2019. 51(4):638-654.e9. doi: 10.1016/j.immuni.2019.08.017.

Wen Y, Lu X, Ren J, Privratsky JR, Yang B, Rudemiller NP, Zhang J, Griffiths R, Jain MK, Nedospasov SA, Liu BC, Crowley SD. KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. J Am Soc Nephrol. 2019. 30(10):1925-1938. doi: 10.1681/ASN.2019020111.

Belousov PV, Afanasyeva MA, Gubernatorova EO, Bogolyubova AV, Uvarova AN, Putlyaeva LV, Ramanauskaite EM, Kopylov AT, Demin DE, Tatosyan KA, Ustiugova AS, Prokofjeva MM, Lanshchakov KV, Vanushko VE, Zaretsky AR, Severskaia NV, Dvinskikh NY, Abrosimov AY, Kuprash DV, Schwartz AM. Multi-dimensional immunoproteomics coupled with in vitro recapitulation of oncogenic NRASQ61R identifies diagnostically relevant autoantibody biomarkers in thyroid neoplasia. Cancer Letters. 2019. 467:96-106. doi: 10.1016/j.canlet.2019.07.013.

Gubernatorova EO, Namakanova OA, Tumanov AV, Drutskaya MS, Nedospasov SA. Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. Immunol Lett. 2019 Mar;207:73-83. doi: 10.1016/j.imlet.2018.11.012.

Maslennikova SO, Gerlinskaya LA, Kontsevaya GV, Anisimova MV, Nedospasov SA, Feofanova NA, Moshkin MP, Moshkin YM. TNFα is responsible for the canonical offspring number-size trade-off. Sci Rep. 2019 Mar 14;9(1):4568. doi: 10.1038/s41598-019-38844-9.

Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol. 2019 Feb;20(2):129-140. doi: 10.1038/s41590-018-0288-7.

2018

Drutskaya MS, Efimov GA, Astrakhantseva IV, Kruglov AA, Nedospasov SA. Making anti-cytokine therapy more selective: Studies in mice. Cytokine. 2018 Jan;101:33-38. doi: 10.1016/j.cyto.2016.08.022.

Atretkhany KN, Mufazalov IA, Dunst J, Kuchmiy A, Gogoleva VS, Andruszewski D, Drutskaya MS, Faustman DL, Schwabenland M, Prinz M, Kruglov AA, Waisman A, Nedospasov SA. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13051-13056. doi: 10.1073/pnas.1807499115.

Gogoleva VS, Atretkhany KN, Drutskaya MS, Mufazalov IA, Kruglov AA, Nedospasov SA. Cytokines as Mediators of Neuroinflammation in Experimental Autoimmune Encephalomyelitis. Biochemistry (Mosc). 2018 Sep;83(9):1089-1103. doi: 10.1134/S0006297918090110.

Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RV, Hidalgo J, Drutskaya MS, Tumanov AV, Nedospasov SA. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Front Immunol. 2018 Nov 26;9:2718. doi: 10.3389/fimmu.2018.02718.

Nosenko MA, Moysenovich AM, Zvartsev RV, Arkhipova AY, Zhdanova AS, Agapov II, Vasilieva TV, Bogush VG, Debabov VG, Nedospasov SA, Moisenovich MM, Drutskaya MS. Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis. Front Immunol. 2018 Dec 4;9:2851. doi: 10.3389/fimmu.2018.02851.

Zvartsev RV, Korshunova DS, Gorshkova EA, Nosenko MA, Korneev KV, Maksimenko OG, Korobko IV, Kuprash DV, Drutskaya MS, Nedospasov SA, Deikin AV. Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells. Dokl Biochem Biophys. 2018 Nov;483(1):344-347. doi: 10.1134/S1607672918060157.

Drutskaya MS, Gogoleva VS, Atretkhany KN, Gubernatorova EO, Zvartsev RV, Nosenko MA, Nedospasov SA. [Proinflammatory and Immunoregulatory Functions of Interleukin 6 as Identified by Reverse Genetics]. Mol Biol (Mosk). 2018 Nov-Dec;52(6):963-974. doi: 10.1134/S0026898418060058.

Korneev KV, Kondakova AN, Sviriaeva EN, Mitkin NA, Palmigiano A, Kruglov AA, Telegin GB, Drutskaya MS, Sturiale L, Garozzo D, Nedospasov SA, Knirel YA, Kuprash DV. Hypoacylated LPS from Foodborne Pathogen Campylobacter jejuni Induces Moderate TLR4-Mediated Inflammatory Response in Murine Macrophages. Front Cell Infect Microbiol. 2018 Feb 27;8:58. doi: 10.3389/fcimb.2018.00058.

Dudeck J, Froebel J, Kotrba J, Lehmann CHK, Dudziak D, Speier S, Nedospasov SA, Schraven B, Dudeck A. Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency. J Allergy Clin Immunol. 2018 Oct 17. pii: S0091-6749(18)31443-X. doi: 10.1016/j.jaci.2018.08.052.

Schaeuble K, Britschgi MR, Scarpellino L, Favre S, Xu Y, Koroleva E, Lissandrin TKA, Link A, Matloubian M, Ware CF, Nedospasov SA, Tumanov AV, Cyster JG, Luther SA. Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells. Cell Rep. 2017 Nov 28;21(9):2500-2514. doi: 10.1016/j.celrep.2017.10.119.

2017

Kruglov AA, Nedospasov SA. Cytokine neutralization at specific cellular source : A new therapeutic paradigm? Z Rheumatol. 2017 Mar;76(Suppl 1):22-24. doi: 10.1007/s00393-016-0215-y.

Drutskaya MS, Efimov GA, Kruglov AA, Nedospasov SA. Can we design a better anti-cytokine therapy? J Leukoc Biol. 2017 Sep;102(3):783-790. doi: 10.1189/jlb.3MA0117-025R.

Nosenko MA, Atretkhany KN, Mokhonov VV, Efimov GA, Kruglov AA, Tillib SV, Drutskaya MS, Nedospasov SA. VHH-Based Bispecific Antibodies Targeting Cytokine Production. Front Immunol. 2017 Sep 1;8:1073. doi: 10.3389/fimmu.2017.01073.

Nosenko MA, Maluchenko NV, Drutskaya MS, Arkhipova AY, Agapov II, Nedospasov SA, Moisenovich MM. Induction of ICAM-1 Expression in Mouse Embryonic Fibroblasts Cultured on Fibroin-Gelatin Scaffolds. Acta Naturae. 2017 Jul-Sep;9(3):89-93.

Wang X, Chen H, Tian R, Zhang Y, Drutskaya MS, Wang C, Ge J, Fan Z, Kong D, Wang X, Cai T, Zhou Y, Wang J, Wang J, Wang S, Qin Z, Jia H, Wu Y, Liu J, Nedospasov SA, Tredget EE, Lin M, Liu J, Jiang Y, Wu Y. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nat Commun. 2017 Mar 27;8:14091. doi: 10.1038/ncomms14091.

Korneev KV, Atretkhany KN, Drutskaya MS, Grivennikov SI, Kuprash DV, Nedospasov SA. TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis. Cytokine. 2017 Jan;89:127-135. doi: 10.1016/j.cyto.2016.01.021.

Kuprash DV, Garib FY, Nedospasov SA. [Antibody-Based Drugs and Other Recombinant Proteins for Diagnostics and Therapy of Viral Infections, Autoimmune Diseases and Cancer]. Mol Biol (Mosk). 2017 Nov-Dec;51(6):883-885. doi: 10.7868/S0026898417060015.

Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S. Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med. 2017 Apr 3;214(4):905-917. doi: 10.1084/jem.20160499.

Shebzukhov YV, Stanislawiak S, Bezhaeva TR, Nedospasov SA, Kuprash DV. Low level of Lck kinase in Th2 cells limits expression of CD4 co-receptor and S73 phosphorylation of transcription factor c-Jun. Sci Rep. 2017 May 24;7(1):2339. doi: 10.1038/s41598-017-02553-y.

Kuprash DV, Garib FY, Nedospasov SA. [Antibody-Based Drugs and Other Recombinant Proteins for Diagnostics and Therapy of Viral Infections, Autoimmune Diseases and Cancer]. Mol Biol (Mosk). 2017 Nov-Dec;51(6):883-885. doi: 10.7868/S0026898417060015.

Efimov GA, Raats JMH, Chirivi RGS, van Rosmalen JWG, Nedospasov SA. [Humanization of Murine Monoclonal anti-hTNF Antibody: The F10 Story]. Mol Biol (Mosk). 2017 Nov-Dec;51(6):1062-1068. doi: 10.7868/S0026898417060167.

2016

Atretkhany KS, Nosenko MA, Gogoleva VS, Zvartsev RV, Qin Z, Nedospasov SA, Drutskaya MS. TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation. Front Immunol. 2016 Apr 19;7:147. doi: 10.3389/fimmu.2016.00147.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA. Cell type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source. Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3006-11. doi: 10.1073/pnas.1520175113.

Atretkhany KN, Drutskaya MS, Nedospasov SA, Grivennikov SI, Kuprash DV. Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironment. Pharmacol Ther. 2016 Dec;168:98-112. doi: 10.1016/j.pharmthera.2016.09.011.

Sviriaeva EN, Korneev KV, Drutskaya MS, Kuprash DV. Mechanisms of Changes in Immune Response during Bacterial Coinfections of the Respiratory Tract. Biochemistry (Mosc). 2016 Nov;81(11):1340-1349.

Atretkhany KN, Drutskaya MS. Myeloid-Derived Suppressor Cells and Proinflammatory Cytokines as Targets for Cancer Therapy. Biochemistry (Mosc). 2016 Nov;81(11):1274-1283.

Sviriaeva EN, Korneev KV, Drutskaya MS, Nedospasov SA, Kuprash DV. Modeling of viral-bacterial coinfections at the molecular level using agonists of innate immunity receptors. Dokl Biochem Biophys. 2016 Nov;471(1):393-395. doi: 10.1134/S1607672916060053.

Nosenko MA, Drutskaya MS, Moisenovich MM, Nedospasov SA. Bioengineering of Artificial Lymphoid Organs. Acta Naturae. 2016 Apr-Jun;8(2):10-23.

Arkhipova AY, Kotlyarova MC, Novichkova SG, Agapova OI, Kulikov DA, Kulikov AV, Drutskaya MS, Agapov II, Moisenovich MM. New Silk Fibroin-Based Bioresorbable Microcarriers. Bull Exp Biol Med. 2016 Feb;160(4):491-4. doi: 10.1007/s10517-016-3204-x.

Zhang J, Rudemiller NP, Patel MB, Wei Q, Karlovich NS, Jeffs AD, Wu M, Sparks MA, Privratsky JR, Herrera M, Gurley SB, Nedospasov SA, Crowley SD. Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol. 2016 Aug;27(8):2257-64. doi: 10.1681/ASN.2015060683.

Gorshkova EA, Nedospasov SA, Shilov ES. [Evolutionary plasticity of IL-6 cytokine family]. Mol Biol (Mosk). 2016 Nov-Dec;50(6):1039-1048. doi: 10.7868/S0026898416060069.

Kuprash DV, Nedospasov SA. Molecular and Cellular Mechanisms of Inflammation. Biochemistry (Mosc). 2016 Nov;81(11):1237-1239.

Arkhipova AY, Nosenko MA, Malyuchenko NV, Zvartsev RV, Moisenovich AM, Zhdanova AS, Vasil’eva TV, Gorshkova EA, Agapov II, Drutskaya MS, Nedospasov SA, Moisenovich MM. Effects of Fibroin Microcarriers on Inflammation and Regeneration of Deep Skin Wounds in Mice. Biochemistry (Mosc). 2016 Nov;81(11):1251-1260.

Yuzhakova DV, Shirmanova MV, Bocharov AA, Astrakhantseva IV, Vasilenko EA, Gorshkova EN, Drutskaya MS, Zagaynova EV, Nedospasov SA, Kruglov AA. Microbiota Induces Expression of Tumor Necrosis Factor in Postnatal Mouse Skin. Biochemistry (Mosc). 2016 Nov;81(11):1303-1308.

2015

Lemos, D.R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S.T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S.A., Rossi, F.M.V. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015, 21(7): 786-794.

Drutskaya MS, Nosenko MA, Atretkhany KS, Efimov GA, Nedospasov SA. [Interleukin-6: From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting]. Mol Biol (Mosk). 2015 Nov-Dec;49(6):937-43. doi: 10.7868/S0026898415060063. Russian.

Korneev KV, Arbatsky NP, Molinaro A, Palmigiano A, Shaikhutdinova RZ, Shneider MM, Pier GB, Kondakova AN, Sviriaeva EN, Sturiale L, Garozzo D, Kruglov AA, Nedospasov SA, Drutskaya MS, Knirel YA, Kuprash DV. Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa. Front Immunol. 2015 Nov 23;6:595. doi: 10.3389/fimmu.2015.00595.

Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux VF, Nedospasov SA, Garcia I. Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Factor (TNF) but Not Mouse TNF. Infect Immun. 2015 Sep;83(9):3612-23. doi: 10.1128/IAI.00743-15.

Dudeck J, Ghouse SM, Lehmann CH, Hoppe A, Schubert N, Nedospasov SA, Dudziak D, Dudeck A. Mast-Cell-Derived TNF Amplifies CD8(+) Dendritic Cell Functionality and CD8(+) T Cell Priming. Cell Rep. 2015 Oct 13;13(2):399-411. doi: 10.1016/j.celrep.2015.08.078.

Awad AS, You H, Gao T, Cooper TK, Nedospasov SA, Vacher J, Wilkinson PF, Farrell FX, Brian Reeves W. Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury. Kidney Int. 2015 Oct;88(4):722-33. doi: 10.1038/ki.2015.162.

Belousov PV, Bogolyubova AV, Kim YS, Abrosimov AY, Kopylov AT, Tvardovskiy AA, Lanshchakov KV, Sazykin AY, Dvinskikh NY, Bobrovskaya YI, Selivanova LS, Shilov ES, Schwartz AM, Shebzukhov YV, Severskaia NV, Vanushko VE, Moshkovskii SA, Nedospasov SA, Kuprash DV. Serum Immunoproteomics Combined With Pathological Reassessment of Surgical Specimens Identifies TCP-1ζ Autoantibody as a Potential Biomarker in Thyroid Neoplasia. J Clin Endocrinol Metab. 2015 Sep;100(9):E1206-15. doi: 10.1210/jc.2014-4260.

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie ANJ, Caamaño JH. Inflammation-induced formation of fat-associated lymphoid clusters. Nat Immunol. 2015 Aug;16(8):819-828. doi: 10.1038/ni.3215.

Van Praet JT, Donovan E, Vanassche I, Drennan MB, Windels F, Dendooven A, Allais L, Cuvelier CA, van de Loo F, Norris PS, Kruglov AA, Nedospasov SA, Rabot S, Tito R, Raes J, Gaboriau-Routhiau V, Cerf-Bensussan N, Van de Wiele T, Eberl G, Ware CF, Elewaut D. Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015 Feb 12;34(4):466-74. doi: 10.15252/embj.201489966.

Xu HC, Huang J, Khairnar V, Duhan V, Pandyra AA, Grusdat M, Shinde P, McIlwain DR, Maney SK, Gommerman J, Löhning M, Ohashi PS, Mak TW, Pieper K, Sic H, Speletas M, Eibel H, Ware CF, Tumanov AV, Kruglov AA, Nedospasov SA, Häussinger D, Recher M, Lang KS, Lang PA. Deficiency of the B cell-activating factor receptor results in limited CD169+ macrophage function during viral infection. J Virol. 2015 May;89(9):4748-59. doi: 10.1128/JVI.02976-14.

2014

Winsauer C, Kruglov AA, Chashchina AA, Drutskaya MS, Nedospasov SA. Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice. Cytokine Growth Factor Rev. 2014 Apr;25(2):115-23. doi: 10.1016/j.cytogfr.2013.12.005.

Drutskaya MS, Efimov GA, Zvartsev RV, Chashchina AA, Chudakov DM, Tillib SV, Kruglov AA, Nedospasov SA. Experimental models of arthritis in which pathogenesis is dependent on TNF expression. Biochemistry (Mosc). 2014 Dec;79(12):1349-57. doi: 10.1134/S0006297914120086.

Korneev KV, Kondakova AN, Arbatsky NP, Novototskaya-Vlasova KA, Rivkina EM, Anisimov AP, Kruglov AA, Kuprash DV, Nedospasov SA, Knirel YA, Drutskaya MS. Distinct biological activity of lipopolysaccharides with different lipid A acylation status from mutant strains of Yersinia pestis and some members of genus Psychrobacter. Biochemistry (Mosc). 2014 Dec;79(12):1333-8. doi: 10.1134/S0006297914120062.

Drennan MB, Govindarajan S, De Wilde K, Schlenner SM, Ware C, Nedospasov S, Rodewald HR, Elewaut D. The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages. J Immunol. 2014 Dec 15;193(12):5960-72. doi: 10.4049/jimmunol.1401601.

Kruglov AA, Nedospasov SA. Microbiota, intestinal immunity, and mouse bustle. Acta Naturae. 2014 Jan;6(1):6-8.

Shebzukhov YV, Horn K, Brazhnik KI, Drutskaya MS, Kuchmiy AA, Kuprash DV, Nedospasov SA. Dynamic changes in chromatin conformation at the TNF transcription start site in T helper lymphocyte subsets. Eur J Immunol. 2014 Jan;44(1):251-64. doi: 10.1002/eji.201243297.

Shebzukhov YV, Kuchmiy AA, Kruglov AA, Zipp F, Siffrin V, Nedospasov SA. Experimental applications of TNF-reporter mice with far-red fluorescent label. Methods Mol Biol. 2014;1155:151-62. doi: 10.1007/978-1-4939-0669-7_13.

Astrakhantseva IV, Efimov GA, Drutskaya MS, Kruglov AA, Nedospasov SA. Modern anti-cytokine therapy of autoimmune diseases. Biochemistry (Mosc). 2014 Dec;79(12):1308-21. doi: 10.1134/S0006297914120049.

Kondratieva TK, Linge IA, Kondratieva EV, Dyatlov AV, Drutskaya MS, Zvartsev RV, Nedospasov SA, Apt AS. Formation of compact aggregates of B-lymphocytes in lung tissue during mycobacterial infection in mice depends on TNF production by these cells and is not an element of the host’s immunological protection. Biochemistry (Mosc). 2014 Dec;79(12):1358-62. doi: 10.1134/S0006297914120098.

Shilov ES, Kislyakov IV, Gorshkova EA, Zvartsev RV, Drutskaya MS, Mufazalov IA, Skulachev VP, Nedospasov SA. Mouse lymphomyeloid cells can function with significantly decreased expression levels of cytochrome C. Biochemistry (Mosc). 2014 Dec;79(12):1412-22. doi: 10.1134/S0006297914120177.

2013

Laske K, Shebzukhov YV, Grosse-Hovest L, Kuprash DV, Khlgatian SV, Koroleva EP, Sazykin AY, Penkov DN, Belousov PV, Stevanovic S, Vass V, Walter S, Eisel D, Schmid-Horch BD, Nedospasov SA, Rammensee HG, Gouttefangeas C. Alternative variants of human HYDIN are novel cancer-associated antigens recognized by adaptive immunity. Cancer Immunol Res. 2013 Sep;1(3):190-200. doi: 10.1158/2326-6066.CIR-13-0079.

Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science. 2013 Dec 6;342(6163):1243-6. doi: 10.1126/science.1243364.

Allie N, Grivennikov SI, Keeton R, Hsu NJ, Bourigault ML, Court N, Fremond C, Yeremeev V, Shebzukhov Y, Ryffel B, Nedospasov SA, Quesniaux VF, Jacobs M. Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep. 2013;3:1809. doi: 10.1038/srep01809.

Bozrova SV, Levitskiĭ VA, Nedospasov SA, Drutskaia MS. [Imiquimod: the biochemical mechanisms of immunomodulatory and anti-inflammatory activity]. Biomed Khim. 2013 May-Jun;59(3):249-66.

Kondakova AN, Drutskaya MS, Shashkov AS, Nedospasov SA, Akimov VN, Arbatsky NP, Galchenko VF, Knirel YA. Structure of the O-polysaccharide of Pseudomonas mandelii CYar1 containing 3,6-dideoxy-4-C-[(S)-1-hydroxyethyl]-D-xylo-hexose (yersiniose A). Carbohydr Res. 2013 Nov 15;381:138-41. doi: 10.1016/j.carres.2013.08.016.

Rothe M, Quarcoo D, Chashchina AA, Bozrova SV, Qin Z, Nedospasov SA, Blankenstein T, Kammertoens T, Drutskaya MS. IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis. Cancer Med. 2013 Dec;2(6):815-25. doi: 10.1002/cam4.145.

2012

Kondakova AN, Novototskaya-Vlasova KA, Arbatsky NP, Drutskaya MS, Shcherbakova VA, Shashkov AS, Gilichinsky DA, Nedospasov SA, Knirel YA. Structure of the O-specific polysaccharide from the lipopolysaccharide of Psychrobacter cryohalolentis K5(T) containing a 2,3,4-triacetamido-2,3,4-trideoxy-L-arabinose moiety. J Nat Prod. 2012 Dec 28;75(12):2236-40. doi: 10.1021/np300484m.

Kuchmiy AA, Efimov GA, Nedospasov SA. Methods for in vivo molecular imaging. Biochemistry (Mosc). 2012 Dec;77(12):1339-53. doi: 10.1134/S0006297912120012.

Kondakova AN, Novototskaya-Vlasova KA, Shashkov AS, Drutskaya MS, Senchenkova SN, Shcherbakova VA, Gilichinsky DA, Nedospasov SA, Knirel YA. Structure of an acidic polysaccharide isolated from Psychrobacter maritimus 3pS containing a bacillosamine derivative. Carbohydr Res. 2012 Oct 1;359:7-10. doi: 10.1016/j.carres.2012.07.007.

Kondakova AN, Novototskaya-Vlasova KA, Drutskaya MS, Senchenkova SN, Shcherbakova VA, Shashkov AS, Gilichinsky DA, Nedospasov SA, Knirel YA. Structure of the O-polysaccharide chain of the lipopolysaccharide of Psychrobacter muricolla 2pS(T) isolated from overcooled water brines within permafrost. Carbohydr Res. 2012 Feb 15;349:78-81. doi: 10.1016/j.carres.2011.11.027.

Kruglov AA, Nedospasov SA. Comment on «experimental arthritis triggers periodontal disease in mice: involvement of TNF-α and the oral microbiota». J Immunol. 2012 Jan 1;188(1):4-5; author reply 5-6. doi: 10.4049/jimmunol.1190080

2011

Guk KD, Kuprash DV. [Interleukin-11, an IL-6 like cytokine]. Mol Biol (Mosk). 2011 Jan-Feb;45(1):44-55.

Shebzukhov IuV, Kuprash DV. [Transcriptional regulation of TNF/LT locus in immune cells]. Mol Biol (Mosk). 2011 Jan-Feb;45(1):56-67.

Kruglov AA, Tumanov AV, Grivennikov SI, Shebzukhov YV, Kuchmiy AA, Efimov GA, Drutskaya MS, Scheller J, Kuprash DV, Nedospasov SA. Modalities of experimental TNF blockade in vivo: mouse models. Adv Exp Med Biol. 2011;691:421-31. doi: 10.1007/978-1-4419-6612-4_44.

Kruglov, A.A., Lampropoulou, V., Fillatreau, S. and Nedospasov, S.A. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J. Immunol. 2011, 187: 5660-5670.

Widenmeyer M, Shebzukhov Y, Haen SP, Schmidt D, Clasen S, Boss A, Kuprash DV, Nedospasov SA, Stenzl A, Aebert H, Wernet D, Stevanović S, Pereira PL, Rammensee HG, Gouttefangeas C. Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation. Int J Cancer. 2011 Jun 1;128(11):2653-62. doi: 10.1002/ijc.25601.

Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J. ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnol J. 2011 Jan;9(1):22-31. doi: 10.1111/j.1467-7652.2010.00523.x.

Nedospasov SA. [Molecular Immunology- the centuries and sciences borders]. Mol Biol (Mosk). 2011 Jan-Feb;45(1):3-6.

Drutskaia MS, Belousov PV, Nedospasov SA. [Innate immunity against viruses]. Mol Biol (Mosk). 2011 Jan-Feb;45(1):7-19.

2010

Drutskaya MS, Efimov GA, Kruglov AA, Kuprash DV, Nedospasov SA. Tumor necrosis factor, lymphotoxin and cancer. IUBMB Life. 2010 Apr;62(4):283-9. doi: 10.1002/iub.309.

Wang Y, Koroleva EP, Kruglov AA, Kuprash DV, Nedospasov SA, Fu YX, Tumanov AV. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity. 2010 Mar 26;32(3):403-13. doi: 10.1016/j.immuni.2010.02.011.

Tumanov AV, Grivennikov SI, Kruglov AA, Shebzukhov YV, Koroleva EP, Piao Y, Cui CY, Kuprash DV, Nedospasov SA. Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs. Blood. 2010 Nov 4;116(18):3456-64. doi: 10.1182/blood-2009-10-249177.

Belousov PV, Kuprash DV, Nedospasov SA, Shebzukhov YV. Autoantibodies to tumor-associated antigens as cancer biomarkers. Curr Mol Med. 2010 Mar;10(2):115-22.

Quesniaux VF, Jacobs M, Allie N, Grivennikov S, Nedospasov SA, Garcia I, Olleros ML, Shebzukhov Y, Kuprash D, Vasseur V, Rose S, Court N, Vacher R, Ryffel B. TNF in host resistance to tuberculosis infection. Curr Dir Autoimmun. 2010;11:157-79. doi: 10.1159/000289204.

Arbatsky NP, Kondakova AN, Shashkov AS, Drutskaya MS, Belousov PV, Nedospasov SA, Petrova MA, Knirel YA. Structure of the O-antigen of Acinetobacter lwoffii EK30A; identification of d-homoserine, a novel non-sugar component of bacterial polysaccharides. Org Biomol Chem. 2010 Aug 7;8(15):3571-7. doi: 10.1039/c004090h.

2009

Liepinsh DJ, Kruglov AA, Galimov AR, Shakhov AN, Shebzukhov YV, Kuchmiy AA, Grivennikov SI, Tumanov AV, Drutskaya MS, Feigenbaum L, Kuprash DV, Nedospasov SA. Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus. Eur J Immunol. 2009 Oct;39(10):2906-15. doi: 10.1002/eji.200839191.

Efimov GA, Kruglov AA, Tillib SV, Kuprash DV, Nedospasov SA. Tumor Necrosis Factor and the consequences of its ablation in vivo. Mol Immunol. 2009 Nov;47(1):19-27. doi: 10.1016/j.molimm.2009.01.007.

Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J. Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity. J Biotechnol. 2009 Jun 15;142(2):170-8. doi: 10.1016/j.jbiotec.2009.04.002.

Mufazalov IA, Pen’kov DN, Cherniak BV, Pletiushkina OIu, Vysokikh MIu, Kirpichnikov MP, Dolgikh DA, Kruglov AA, Kuprash DV, Skulachev VP, Nedospasov SA. [Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome C gene]. Mol Biol (Mosk). 2009 Jul-Aug;43(4):648-56.

2008

Belousov PV, Kuprash DV, Sazykin AY, Khlgatian SV, Penkov DN, Shebzukhov YV, Nedospasov SA. Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors. Biochemistry (Mosc). 2008 May;73(5):562-72.

Kruglov AA, Kuchmiy A, Grivennikov SI, Tumanov AV, Kuprash DV, Nedospasov SA. Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):231-44. doi: 10.1016/j.cytogfr.2008.04.010.

Shebzukhov YV, Lavrik IN, Karbach J, Khlgatian SV, Koroleva EP, Belousov PV, Kashkin KN, Knuth A, Jager E, Chi NW, Kuprash DV, Nedospasov SA. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. Cancer Immunol Immunother. 2008 Jun;57(6):871-81.

Galimov AR, Kruglov AA, Bol’sheva NL, Iurkevich OIu, Lipin’sh DIa, Mufazalov IA, Kuprash DV, Nedospasov SA. [Chromosomal localization and molecular organization of human genomic fragment containing TNF/LT locus in transgenic mice]. Mol Biol (Mosk). 2008 Jul-Aug;42(4):629-38.

Kuprash DV, Qin Z, Ito D, Grivennikov SI, Abe K, Drutskaya LN, Blankenstein T, Nedospasov SA. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice. Cancer Lett. 2008 Sep 8;268(1):70-5. doi: 10.1016/j.canlet.2008.03.023.

Jungbeck M, Stopfer P, Bataille F, Nedospasov SA, Männel DN, Hehlgans T. Blocking lymphotoxin beta receptor signalling exacerbates acute DSS-induced intestinal inflammation—opposite functions for surface lymphotoxin expressed by T and B lymphocytes. Mol Immunol. 2008 Jan;45(1):34-41.

2007

Belousov PV, Shebzukhov IuV, Nedospasov SA, Kuprash DV. [Onconeural antibodies as a tool for diagnosis of malignant tumors and paraneoplastic neurological disorders]. Mol Gen Mikrobiol Virusol. 2007;(2):6-13.

Shebzukhov IuV, Belousov PV, Khlgatian SV, Sazykin AIu, Kuprash DV, Nedospasov SA. [Contemporary molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens]. Mol Gen Mikrobiol Virusol. 2007;(2):3-6.

Nedospasov SA, Kuprash DV. [Oncoimmunology: some fundamental problems of cancer immunotherapy]. Mol Biol (Mosk). 2007 Mar-Apr;41(2):355-68.

Kashkin KN, Khlgatian SV, Gurova OV, Kuprash DV, Nedospasov SA. New mutations in the human p53 gene—a regulator of the cell cycle and carcinogenesis. Biochemistry (Mosc). 2007 Mar;72(3):282-92.

Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Sazykin AY, Kadachigova TS, Pomerantseva EA, Lagarkova MA, Nedospasov SA, Kuprash DV. RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity. Cancer Lett. 2007 Oct 8;255(2):255-62.

2006

Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA. Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms. Int Rev Cytol. 2006;252:129-61.

Welniak LA, Kuprash DV, Tumanov AV, Panoskaltsis-Mortari A, Blazar BR, Sun K, Nedospasov SA, Murphy WJ. Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation. Blood. 2006 Jan 1;107(1):410-2. Epub 2005 Sep 13.

Liepinsh DJ, Grivennikov SI, Klarmann KD, Lagarkova MA, Drutskaya MS, Lockett SJ, Tessarollo L, McAuliffe M, Keller JR, Kuprash DV, Nedospasov SA. Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol. 2006 Jun;26(11):4214-25.

Junt T, Tumanov AV, Harris N, Heikenwalder M, Zeller N, Kuprash DV, Aguzzi A, Ludewig B, Nedospasov SA, Zinkernagel RM. Expression of lymphotoxin beta governs immunity at two distinct levels. Eur J Immunol. 2006 Aug;36(8):2061-75.

2005

Drutskaya MS, Ortiz M, Liepinsh DJ, Kuprash DV, Nedospasov SA, Keller JR. Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-deficient mice. Exp Hematol. 2005 Nov;33(11):1348-56.

Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya LN, Förster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity. 2005 Jan;22(1):93-104.

Kuprash DV, Tumanov AV, Liepinsh DJ, Koroleva EP, Drutskaya MS, Kruglov AA, Shakhov AN, Southon E, Murphy WJ, Tessarollo L, Grivennikov SI, Nedospasov SA. Novel tumor necrosis factor-knockout mice that lack Peyer’s patches. Eur J Immunol. 2005 May;35(5):1592-600.

Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG, Brennan ML, Golovkina TV, Rokhlin OW, Kuprash DV, Nedospasov SA, Hazen SL, Feinstein E, Gudkov AV. p53 is a suppressor of inflammatory response in mice. FASEB J. 2005 Jun;19(8):1030-2. Epub 2005 Apr 5.

Shebzukhov YV, Koroleva EP, Khlgatian SV, Lagarkova MA, Meshcheryakov AA, Lichinitser MR, Karbach J, Jager E, Kuprash DV, Nedospasov SA. Humoral immune response to thymidylate synthase in colon cancer patients after 5-FU chemotherapy. Immunol Lett. 2005 Aug 15;100(1):88-93.

Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Kuz’mina KE, Radko BV, Longpre F, Lagarkova MA, Kadachigova TS, Gurova OV, Meshcheryakov AA, Lichinitser MR, Knuth A, Jager E, Kuprash DV, Nedospasov SA. Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. Int J Cancer. 2005 Dec 10;117(5):800-6.

2004

Shakhov AN, Rybtsov S, Tumanov AV, Shulenin S, Dean M, Kuprash DV, Nedospasov SA. SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur J Immunol. 2004 Feb;34(2):494-503.

Koroleva EP, Lagar’kova MA, Khlgatian SV, Shebzukhov IuV, Meshcheriakov AA, lichinitser MR, Nedospasov SA, Kuprash DV. [Serological study of a repertoire of human cancer antigens and autoantigens]. Mol Biol (Mosk). 2004 Mar-Apr;38(2):233-8.

Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer’s patches. J Immunol. 2004 Jul 1;173(1):86-91.

2003

Tumanov AV, Grivennikov SI, Shakhov AN, Rybtsov SA, Koroleva EP, Takeda J, Nedospasov SA, Kuprash DV. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev. 2003 Oct;195:106-16.

Lagarkova MA, Koroleva EP, Kuprash DV, Boitchenko VE, Kashkarova UA, Nedospasov SA, Shebzukhov YV. Evaluation of humoral response to tumor antigens using recombinant expression-based serological mini-arrays (SMARTA). Immunol Lett. 2003 Jan 2;85(1):71-4.

Abe K, Yarovinsky FO, Murakami T, Shakhov AN, Tumanov AV, Ito D, Drutskaya LN, Pfeffer K, Kuprash DV, Komschlies KL, Nedospasov SA. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood. 2003 Feb 15;101(4):1477-83.

Tumanov AV, Kuprash DV, Nedospasov SA. The role of lymphotoxin in development and maintenance of secondary lymphoid tissues. Cytokine Growth Factor Rev. 2003 Jun-Aug;14(3-4):275-88.

2002

Kuprash DV, Alimzhanov MB, Tumanov AV, Grivennikov SI, Shakhov AN, Drutskaya LN, Marino MW, Turetskaya RL, Anderson AO, Rajewsky K, Pfeffer K, Nedospasov SA. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol. 2002 Dec;22(24):8626-34.

Kuprash DV, Boitchenko VE, Yarovinsky FO, Rice NR, Nordheim A, Rühlmann A, Nedospasov SA. Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin beta, in human peripheral blood mononuclear cells. Blood. 2002 Sep 1;100(5):1721-7.

Tumanov A, Kuprash D, Lagarkova M, Grivennikov S, Abe K, Shakhov A, Drutskaya L, Stewart C, Chervonsky A, Nedospasov S. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity. 2002 Sep;17(3):239-50.

Koroleva EP, Lagarkova MA, Mesheryakov AA, Scanlan MJ, Old LJ, Nedospasov SA, Kuprash DV. Serological identification of antigens associated with renal cell carcinoma. Russ J Immunol. 2002 Oct;7(3):229-38.

2001

Boĭchenko VE, Alimzhanov MB, Turetskaia RL, Rulman A, Nordhaim A, Kuprash DV, Nedospasov SA. [Comparative characteristics of transcription of genes for alpha and beta-lymphotoxin subunits in B- and T-lymphocyte lines, in peripheral lymphocytes, and in normal human tissue]. Mol Biol (Mosk). 2001 Jan-Feb;35(1):128-35.

Kuimov AN, Kuprash DV, Petrov VN, Vdovichenko KK, Scanlan MJ, Jongeneel CV, Lagarkova MA, Nedospasov SA. Cloning and characterization of TNKL, a member of tankyrase gene family. Genes Immun. 2001 Feb;2(1):52-5.

Drutskaya MS, Kuprash DV, Nedospasov SA, Chertkov IL, Drize NI. Abnormal hemopoiesis in long-term bone marrow culture from tumor necrosis factor-deficient mice. Bull Exp Biol Med. 2001 Feb;131(2):150-2.

Shakhov AN, Lefgen H, Drutskaya LN, Kuprash DV, Nedospasov SA. Transcriptional Regulation of the Gene, Encoding p40 Subunit of IL-12 and IL-23, in Murine Macrophages. Russ J Immunol. 2001 Dec;6(4):357-366.

2000

Eskdale J, Turestkaya RL, Armstrong C, Kuprash DV, Nedospasov SA, Gallagher G. A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a. Genes Immun. 2000 Feb;1(3):228-30.

Drize NI, Drutskaya MS, Gerasimova LP, Manakova TE, Chertkov IL, Turetskaya RL, Kuprash DV, Nedospasov SA. Changes in the hemopoietic system of mice deficient for tumor necrosis factor or lymphotoxin-alpha. Bull Exp Biol Med. 2000 Jul;130(7):676-8.

Boitchenko VE, Korobko VG, Prassolov VS, Kravchenko VV, Kuimov AN, Turetskaya RL, Kuprash DV, Nedospasov SA. Immunodetection of Murine Lymphotoxins in Eukaryotic Cells. Russ J Immunol. 2000 Oct;5(3):259-266.

1999

Kuprash DV, Alimzhanov MB, Tumanov AV, Anderson AO, Pfeffer K, Nedospasov SA. TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol. 1999 Dec 15;163(12):6575-80.

Kuprash DV, Udalova IA, Turetskaya RL, Kwiatkowski D, Rice NR, Nedospasov SA. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J Immunol. 1999 Apr 1;162(7):4045-52.

Korobko VG, Boĭchenko VE, Kuprash DV, Turetskaia RL, Nedospasov SA. [Heterologous expression of murine lymphotoxins in Escherichia coli and preparation of antibodies]. Bioorg Khim. 1999 Apr;25(4):270-4.

1997

Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, Rajewsky K, Nedospasov SA, Pfeffer K. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9302-7.

1996

Kuprash DV, Osipovich OA, Pokholok DK, Alimzhanov MB, Biragyn A, Turetskaya RL, Nedospasov SA. Functional analysis of the lymphotoxin-beta promoter. Sequence requirements for PMA activation. J Immunol. 1996 Apr 1;156(7):2465-72.

Turetskaia RL, Varfolomeev EE, Lopukhina AA, Udalova IA, Kuprash DV, Krasil’nikov AN, Chaplin DD, Nedospasov SA. [A polymorphic markers for the p75 tumor necrosis factor receptor gene: use for analyzing disease linkage]. Dokl Akad Nauk. 1996 Dec;351(4):558-60.