2023

Kruglov A.A., Bondareva M.A., Gogoleva V.S., Semin I.K., Astrakhantseva I.V., Zvartsev R.V., Lunin A.A., Apolokhov V.D., Shustova E.Yu., Volok V.P., Ustyugov A.A., Ishmukhametov A.A., Nedospasov S.A., Kozlovskaya L.I., Drutskaya M.S. Inactivated whole virion vaccine protects K18-hACE2 Tg mice against Omicron SARS-CoV-2 variant via cross-reactive T cells and non-neutralizing antibody responses. Eur J Immunol. 2023. DOI: 10.1002/eji.202350664.

Gorshkova E.A., Gubernatorova E.O., Dvorianinova E.M., Yurakova T.R., Marey M.V., Averina O.A., Holtze S., Hildebrandt T.B., Dmitriev A.A., Drutskaya M.S., Vyssokikh M.Y., Nedospasov S.A. "Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization". Front Immunol. 2023. 14, 1172467. DOI: 10.3389/fimmu.2023.1172467

Gubernatorova E.O., Gorshkova E.A., Bondareva M.A., Podosokorskaya O.A., Sheynova A.D., Yakovleva A.S., Bonch-Osmolovskaya E.A., Nedospasov S.A., Kruglov A.A., Drutskaya M.S. “Akkermansia muciniphila – friend or foe in colorectal cancer?” Front. Immunol. 2023. 14:1303795. DOI: 10.3389/fimmu.2023.1303795.

Astrakhantseva I.V., Ershova A.E., Chuvpilo S.A., Kruglova N.A., Ishmukhametov A.A., Drutskaya M.S., Kozlovskaya L.I., Nedospasov S.A. "SARS-CoV-2 Binding and Neutralization Properties of Peptides Derived from N-Terminus of Human ACE2". Int J Mol Sci. 2023. 24, 9, 8269, DOI: 10.3390/ijms24098269.

2022

Yurakova T.R., Gubernatorova E.O., Gorshkova E.A., Nosenko M.A., Nedospasov S.A., Drutskaya M.S. HDM induces distinct immunometabolic phenotype in macrophages in TLR4-dependent manner. BBA-Mol Basis Dis. 2022. 1868, 12 166531, DOI: 10.1016/j.bbadis.2022.166531

Gogoleva V.S., Kuprash D.V., Grivennikov S.I., Tumanov A.V., Kruglov A.A., Nedospasov S.A. LTα, TNF, and ILC3 in Peyer’s Patch Organogenesis. Cells. 2022. 11, 1970, DOI: 10.3390/cells11121970

Namakanova O.A., Gorshkova E.A., Zvartsev R.V., Nedospasov S.A., Drutskaya M.S., Gubernatorova E.O. Therapeutic Potential of Combining IL-6 and TNF Blockade in a Mouse Model of Allergic Asthma. Int J Mol Sci. 2022. 23, 73521, DOI: 10.3390/ijms23073521

Lechner A., Henkel F.D.R., Hartung F., Bohnacker S., Alessandrini F., Gubernatorova E.O., Drutskaya M.S., Angioni C., Schreiber Y., Haimerl P., Ge Y., Thomas D., Kabat A.M., Pearce E.J., Ohnmacht C., Nedospasov S.A., Murray P.J., Chaker A.M., Schmidt-Weber C.B., Esser-von Bieren J. Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma. J Allergy Clin Immunol. 2022. 149, 6, 2078 - 2090 DOI: 10.1016/j.jaci.2021.11.026

Krut VG, Chuvpilo SA, Astrakhantseva IV, Kozlovskaya LI, Efimov GA, Kruglov AA, Drutskaya MS, Nedospasov SA. Will Peptides Help to Stop COVID-19? Biochemistry (Mosc). 2022. 87(7):590-604. doi: 10.1134/S0006297922070021.

2021

Gogoleva V.S., Atretkhany K.N., Dygay A.P., Yurakova T.R., Drutskaya M.S., Nedospasov S.A. Current Perspectives on the Role of TNF in Hematopoiesis Using Mice With Humanization of TNF/LT System. Front Immunol. 2021. 12, 661900, DOI: 10.3389/fimmu.2021.661900

Gubernatorova E.O., Namakanova O.A., Gorshkova E.A., Medvedovskaya A.D., Nedospasov S.A., Drutskaya M.S. Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases. Front Immunol. 2021. 1218, 601842, DOI: 10.3389/fimmu.2021.601842

Gubernatorova E.O., Polinova A.I., Petropavlovskiy M.M., Namakanova O.A., Medvedovskaya A.D., Zvartsev R.V., Telegin G.B., Drutskaya M.S., Nedospasov S.A. Dual role of TNF and LTα in carcinogenesis as implicated by studies in mice. Cancers. 2021. 13, 81775, DOI: 10.3390/cancers13081775

Nosenko M.A., Atretkhany K.-S.N., Mokhonov V.V., Chuvpilo S.A., Yanvarev D.V., Drutskaya M.S., Tillib S.V., Nedospasov S.A. Generation and Evaluation of Bispecific Anti-TNF Antibodies Based on Single-Chain VHH Domains. Methods Mol Biol.. 2021. 2248, 91 - 107 DOI: 10.1007/978-1-0716-1130-2_7

Nosenko M.A., Moysenovich A.M., Arkhipova A.Y., Atretkhany K.-S.N., Nedospasov S.A., Drutskaya M.S., Moisenovich M.M. Fibroblasts upregulate expression of adhesion molecules and promote lymphocyte retention in 3D fibroin/gelatin scaffolds. Bioact Mater.. 2021. 6, 10, 3449 - 3460 DOI: 10.1016/j.bioactmat.2021.03.016

2020

Kruglov A., Drutskaya M., Schlienz D., Gorshkova E., Kurz K., Morawietz L., Nedospasov S. Contrasting contributions of TNF from distinct cellular sources in arthritis. Ann Rheum Dis. 2020. 79, 11, 1453 - 1459 DOI: 10.1136/annrheumdis-2019-216068

Drutskaya M.S., Nosenko M.A., Gorshkova E.A., Mokhonov V.V., Zvartsev R.V., Polinova A.I., Kruglov A.A., Nedospasov S.A. Effects of myeloid cell-restricted TNF inhibitors in vitro and in vivo. J Leukoc Biol. 2020. 107, 6, 933 - 939 DOI: 10.1002/JLB.3AB0120-532R

2019

Wen Y, Lu X, Ren J, Privratsky JR, Yang B, Rudemiller NP, Zhang J, Griffiths R, Jain MK, Nedospasov SA, Liu BC, Crowley SD. KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis. J Am Soc Nephrol. 2019. 30(10):1925-1938. doi: 10.1681/ASN.2019020111.

Gubernatorova EO, Namakanova OA, Tumanov AV, Drutskaya MS, Nedospasov SA. Mouse models of severe asthma for evaluation of therapeutic cytokine targeting. Immunol Lett. 2019. 207:73-83. doi: 10.1016/j.imlet.2018.11.012.

Rauwel B., Simons N., Diallo K., Baron M., Degboe Y., Kruglov A., Nedospasov S., Constantin A., Cantagrel A., Davignon J.L. In vivo demonstration of tmTNF reverse signaling: significance in the therapeutic response to anti-TNF agents during murine arthritis. Ann Rheum Dis. 2019 . 78, A14-A15, DOI: 10.1136/annrheumdis-2018-EWRR2019.30

Maslennikova SO, Gerlinskaya LA, Kontsevaya GV, Anisimova MV, Nedospasov SA, Feofanova NA, Moshkin MP, Moshkin YM. TNFα is responsible for the canonical offspring number-size trade-off. Sci Rep. 2019. 9(1):4568. doi: 10.1038/s41598-019-38844-9.

Piliponsky AM, Shubin NJ, Lahiri AK, Truong P, Clauson M, Niino K, Tsuha AL, Nedospasov SA, Karasuyama H, Reber LL, Tsai M, Mukai K, Galli SJ. Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice. Nat Immunol. 2019. 20(2):129-140. doi: 10.1038/s41590-018-0288-7.

2018

Drutskaya MS, Efimov GA, Astrakhantseva IV, Kruglov AA, Nedospasov SA. Making anti-cytokine therapy more selective: Studies in mice. Cytokine. 2018 Jan;101:33-38. doi: 10.1016/j.cyto.2016.08.022.

Atretkhany KN, Mufazalov IA, Dunst J, Kuchmiy A, Gogoleva VS, Andruszewski D, Drutskaya MS, Faustman DL, Schwabenland M, Prinz M, Kruglov AA, Waisman A, Nedospasov SA. Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity. Proc Natl Acad Sci U S A. 2018. 115(51):13051-13056. doi: 10.1073/pnas.1807499115.

Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RV, Hidalgo J, Drutskaya MS, Tumanov AV, Nedospasov SA. Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation. Front Immunol. 2018. 9:2718. doi: 10.3389/fimmu.2018.02718.

Nosenko MA, Moysenovich AM, Zvartsev RV, Arkhipova AY, Zhdanova AS, Agapov II, Vasilieva TV, Bogush VG, Debabov VG, Nedospasov SA, Moisenovich MM, Drutskaya MS. Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis. Front Immunol. 2018. 9:2851. doi: 10.3389/fimmu.2018.02851.

2017

Drutskaya MS, Efimov GA, Kruglov AA, Nedospasov SA. Can we design a better anti-cytokine therapy? J Leukoc Biol. 2017. 102(3):783-790. doi: 10.1189/jlb.3MA0117-025R.

Nosenko MA, Atretkhany KN, Mokhonov VV, Efimov GA, Kruglov AA, Tillib SV, Drutskaya MS, Nedospasov SA. VHH-Based Bispecific Antibodies Targeting Cytokine Production. Front Immunol. 2017. 8:1073. doi: 10.3389/fimmu.2017.01073.

Korneev KV, Atretkhany KN, Drutskaya MS, Grivennikov SI, Kuprash DV, Nedospasov SA. TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis. Cytokine. 2017. 89:127-135. doi: 10.1016/j.cyto.2016.01.021

Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S. Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation. J Exp Med. 2017. 214(4):905-917. doi: 10.1084/jem.20160499.

2016

Atretkhany KS, Nosenko MA, Gogoleva VS, Zvartsev RV, Qin Z, Nedospasov SA, Drutskaya MS. TNF Neutralization Results in the Delay of Transplantable Tumor Growth and Reduced MDSC Accumulation. Front Immunol. 2016. 7:147. doi: 10.3389/fimmu.2016.00147.

Efimov GA, Kruglov AA, Khlopchatnikova ZV, Rozov FN, Mokhonov VV, Rose-John S, Scheller J, Gordon S, Stacey M, Drutskaya MS, Tillib SV, Nedospasov SA. Cell type-restricted anti-cytokine therapy: TNF inhibition from one pathogenic source. Proc Natl Acad Sci U S A. 2016. 113(11):3006-11. doi: 10.1073/pnas.1520175113.

Yuzhakova DV, Shirmanova MV, Bocharov AA, Astrakhantseva IV, Vasilenko EA, Gorshkova EN, Drutskaya MS, Zagaynova EV, Nedospasov SA, Kruglov AA. Microbiota Induces Expression of Tumor Necrosis Factor in Postnatal Mouse Skin. Biochemistry (Mosc). 2016. 81(11):1303-1308. doi: 10.1134/S0006297916110080

2015

Lemos, D.R., Babaeijandaghi, F., Low, M., Chang, C.-K., Lee, S.T., Fiore, D., Zhang, R.-H., Natarajan, A., Nedospasov, S.A., Rossi, F.M.V. Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors. Nat Med. 2015. 21(7): 786-794. doi: 10.1038/nm.3869.

Olleros ML, Chavez-Galan L, Segueni N, Bourigault ML, Vesin D, Kruglov AA, Drutskaya MS, Bisig R, Ehlers S, Aly S, Walter K, Kuprash DV, Chouchkova M, Kozlov SV, Erard F, Ryffel B, Quesniaux VF, Nedospasov SA, Garcia I. Control of Mycobacterial Infections in Mice Expressing Human Tumor Necrosis Factor (TNF) but Not Mouse TNF. Infect Immun. 2015. 83(9):3612-23. doi: 10.1128/IAI.00743-15.

Belousov PV, Bogolyubova AV, Kim YS, Abrosimov AY, Kopylov AT, Tvardovskiy AA, Lanshchakov KV, Sazykin AY, Dvinskikh NY, Bobrovskaya YI, Selivanova LS, Shilov ES, Schwartz AM, Shebzukhov YV, Severskaia NV, Vanushko VE, Moshkovskii SA, Nedospasov SA, Kuprash DV. Serum Immunoproteomics Combined With Pathological Reassessment of Surgical Specimens Identifies TCP-1ζ Autoantibody as a Potential Biomarker in Thyroid Neoplasia. J Clin Endocrinol Metab. 2015. 100(9):E1206-15. doi: 10.1210/jc.2014-4260.

Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie ANJ, Caamaño JH. Inflammation-induced formation of fat-associated lymphoid clusters. Nat Immunol. 2015. 16(8):819-828. doi: 10.1038/ni.3215.

Van Praet JT, Donovan E, Vanassche I, Drennan MB, Windels F, Dendooven A, Allais L, Cuvelier CA, van de Loo F, Norris PS, Kruglov AA, Nedospasov SA, Rabot S, Tito R, Raes J, Gaboriau-Routhiau V, Cerf-Bensussan N, Van de Wiele T, Eberl G, Ware CF, Elewaut D. Commensal microbiota influence systemic autoimmune responses. EMBO J. 2015. 34(4):466-74. doi: 10.15252/embj.201489966.

2014

Winsauer C, Kruglov AA, Chashchina AA, Drutskaya MS, Nedospasov SA. Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice. Cytokine Growth Factor Rev. 2014. 25(2):115-23. doi: 10.1016/j.cytogfr.2013.12.005.

Shebzukhov YV, Horn K, Brazhnik KI, Drutskaya MS, Kuchmiy AA, Kuprash DV, Nedospasov SA. Dynamic changes in chromatin conformation at the TNF transcription start site in T helper lymphocyte subsets. Eur J Immunol. 2014. 44(1):251-64. doi: 10.1002/eji.201243297.

Shebzukhov YV, Kuchmiy AA, Kruglov AA, Zipp F, Siffrin V, Nedospasov SA. Experimental applications of TNF-reporter mice with far-red fluorescent label. Methods Mol Biol. 2014. 1155:151-62. doi: 10.1007/978-1-4939-0669-7_13.

2013

Laske K, Shebzukhov YV, Grosse-Hovest L, Kuprash DV, Khlgatian SV, Koroleva EP, Sazykin AY, Penkov DN, Belousov PV, Stevanovic S, Vass V, Walter S, Eisel D, Schmid-Horch BD, Nedospasov SA, Rammensee HG, Gouttefangeas C. Alternative variants of human HYDIN are novel cancer-associated antigens recognized by adaptive immunity. Cancer Immunol Res. 2013. 1(3):190-200. doi: 10.1158/2326-6066.CIR-13-0079.

Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA. Nonredundant function of soluble LTα3 produced by innate lymphoid cells in intestinal homeostasis. Science. 2013. 342(6163):1243-6. doi: 10.1126/science.1243364.

Allie N, Grivennikov SI, Keeton R, Hsu NJ, Bourigault ML, Court N, Fremond C, Yeremeev V, Shebzukhov Y, Ryffel B, Nedospasov SA, Quesniaux VF, Jacobs M. Prominent role for T cell-derived tumour necrosis factor for sustained control of Mycobacterium tuberculosis infection. Sci Rep. 2013. 3:1809. doi: 10.1038/srep01809.

Rothe M, Quarcoo D, Chashchina AA, Bozrova SV, Qin Z, Nedospasov SA, Blankenstein T, Kammertoens T, Drutskaya MS. IL-13 but not IL-4 signaling via IL-4Rα protects mice from papilloma formation during DMBA/TPA two-step skin carcinogenesis. Cancer Med. 2013. 2(6):815-25. doi: 10.1002/cam4.145.

2012

Kondakova AN, Novototskaya-Vlasova KA, Arbatsky NP, Drutskaya MS, Shcherbakova VA, Shashkov AS, Gilichinsky DA, Nedospasov SA, Knirel YA. Structure of the O-specific polysaccharide from the lipopolysaccharide of Psychrobacter cryohalolentis K5(T) containing a 2,3,4-triacetamido-2,3,4-trideoxy-L-arabinose moiety. J Nat Prod. 2012. 75(12):2236-40. doi: 10.1021/np300484m.

Kuchmiy AA, Efimov GA, Nedospasov SA. Methods for in vivo molecular imaging. Biochemistry (Mosc). 2012. 77(12):1339-53. doi: 10.1134/S0006297912120012.

2011

Kruglov, A.A., Lampropoulou, V., Fillatreau, S. and Nedospasov, S.A. Pathogenic and protective functions of TNF in neuroinflammation are defined by its expression in T lymphocytes and myeloid cells. J. Immunol. 2011. 187: 5660-5670. doi: 10.4049/jimmunol.1100663

Widenmeyer M, Shebzukhov Y, Haen SP, Schmidt D, Clasen S, Boss A, Kuprash DV, Nedospasov SA, Stenzl A, Aebert H, Wernet D, Stevanović S, Pereira PL, Rammensee HG, Gouttefangeas C. Analysis of tumor antigen-specific T cells and antibodies in cancer patients treated with radiofrequency ablation. Int J Cancer. 2011. 128(11):2653-62. doi: 10.1002/ijc.25601.

Conrad U, Plagmann I, Malchow S, Sack M, Floss DM, Kruglov AA, Nedospasov SA, Rose-John S, Scheller J. ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnol J. 2011. 9(1):22-31. doi: 10.1111/j.1467-7652.2010.00523.x.

2010

Wang Y, Koroleva EP, Kruglov AA, Kuprash DV, Nedospasov SA, Fu YX, Tumanov AV. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity. 2010. 32(3):403-13. doi: 10.1016/j.immuni.2010.02.011.

Tumanov AV, Grivennikov SI, Kruglov AA, Shebzukhov YV, Koroleva EP, Piao Y, Cui CY, Kuprash DV, Nedospasov SA. Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs. Blood. 2010. 116(18):3456-64. doi: 10.1182/blood-2009-10-249177.

2009

Liepinsh DJ, Kruglov AA, Galimov AR, Shakhov AN, Shebzukhov YV, Kuchmiy AA, Grivennikov SI, Tumanov AV, Drutskaya MS, Feigenbaum L, Kuprash DV, Nedospasov SA. Accelerated thymic atrophy as a result of elevated homeostatic expression of the genes encoded by the TNF/lymphotoxin cytokine locus. Eur J Immunol. 2009. 39(10):2906-15. doi: 10.1002/eji.200839191.

Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J. Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity. J Biotechnol. 2009. 142(2):170-8. doi: 10.1016/j.jbiotec.2009.04.002.

2008

Kruglov AA, Kuchmiy A, Grivennikov SI, Tumanov AV, Kuprash DV, Nedospasov SA. Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev. 2008. 19(3-4):231-44. doi: 10.1016/j.cytogfr.2008.04.010.

Shebzukhov YV, Lavrik IN, Karbach J, Khlgatian SV, Koroleva EP, Belousov PV, Kashkin KN, Knuth A, Jager E, Chi NW, Kuprash DV, Nedospasov SA. Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients. Cancer Immunol Immunother. 2008. 57(6):871-81. doi: 10.1007/s00262-007-0423-z.

Kuprash DV, Qin Z, Ito D, Grivennikov SI, Abe K, Drutskaya LN, Blankenstein T, Nedospasov SA. Ablation of TNF or lymphotoxin signaling and the frequency of spontaneous tumors in p53-deficient mice. Cancer Lett. 2008. 268(1):70-5. doi: 10.1016/j.canlet.2008.03.023.

2007

Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Sazykin AY, Kadachigova TS, Pomerantseva EA, Lagarkova MA, Nedospasov SA, Kuprash DV. RAP80/UIMC1 as cancer-associated antigen: alternative splice variants and their immunogenicity. Cancer Lett. 2007. 255(2):255-62. doi: 10.1016/j.canlet.2007.04.013.

2006

Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA. Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms. Int Rev Cytol. 2006. 252:129-61. doi: 10.1016/S0074-7696(06)52002-9.

Liepinsh DJ, Grivennikov SI, Klarmann KD, Lagarkova MA, Drutskaya MS, Lockett SJ, Tessarollo L, McAuliffe M, Keller JR, Kuprash DV, Nedospasov SA. Novel lymphotoxin alpha (LTalpha) knockout mice with unperturbed tumor necrosis factor expression: reassessing LTalpha biological functions. Mol Cell Biol. 2006. 26(11):4214-25. doi: 10.1128/MCB.01751-05.

Junt T, Tumanov AV, Harris N, Heikenwalder M, Zeller N, Kuprash DV, Aguzzi A, Ludewig B, Nedospasov SA, Zinkernagel RM. Expression of lymphotoxin beta governs immunity at two distinct levels. Eur J Immunol. 2006. 36(8):2061-75. doi: 10.1002/eji.200626255.

2005

Drutskaya MS, Ortiz M, Liepinsh DJ, Kuprash DV, Nedospasov SA, Keller JR. Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-deficient mice. Exp Hematol. 2005. 33(11):1348-56. doi: 10.1016/j.exphem.2005.08.001.

Grivennikov SI, Tumanov AV, Liepinsh DJ, Kruglov AA, Marakusha BI, Shakhov AN, Murakami T, Drutskaya LN, Förster I, Clausen BE, Tessarollo L, Ryffel B, Kuprash DV, Nedospasov SA. Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects. Immunity. 2005. 22(1):93-104. doi: 10.1016/j.immuni.2004.11.016.

Kuprash DV, Tumanov AV, Liepinsh DJ, Koroleva EP, Drutskaya MS, Kruglov AA, Shakhov AN, Southon E, Murphy WJ, Tessarollo L, Grivennikov SI, Nedospasov SA. Novel tumor necrosis factor-knockout mice that lack Peyer’s patches. Eur J Immunol. 2005. 35(5):1592-600. doi: 10.1002/eji.200526119.

Komarova EA, Krivokrysenko V, Wang K, Neznanov N, Chernov MV, Komarov PG, Brennan ML, Golovkina TV, Rokhlin OW, Kuprash DV, Nedospasov SA, Hazen SL, Feinstein E, Gudkov AV. p53 is a suppressor of inflammatory response in mice. FASEB J. 2005. 19(8):1030-2. Epub 2005 Apr 5. doi: 10.1096/fj.04-3213fje.

Shebzukhov YV, Koroleva EP, Khlgatian SV, Belousov PV, Kuz’mina KE, Radko BV, Longpre F, Lagarkova MA, Kadachigova TS, Gurova OV, Meshcheryakov AA, Lichinitser MR, Knuth A, Jager E, Kuprash DV, Nedospasov SA. Antibody response to a non-conserved C-terminal part of human histone deacetylase 3 in colon cancer patients. Int J Cancer. 2005. 117(5):800-6. doi: 10.1002/ijc.21240.

2004

Shakhov AN, Rybtsov S, Tumanov AV, Shulenin S, Dean M, Kuprash DV, Nedospasov SA. SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur J Immunol. 2004. 34(2):494-503.  doi: 10.1002/eji.200324590.

Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer’s patches. J Immunol. 2004. 173(1):86-91. doi: 10.4049/jimmunol.173.1.86.

2003

Tumanov AV, Grivennikov SI, Shakhov AN, Rybtsov SA, Koroleva EP, Takeda J, Nedospasov SA, Kuprash DV. Dissecting the role of lymphotoxin in lymphoid organs by conditional targeting. Immunol Rev. 2003. 195:106-16. doi: 10.1034/j.1600-065x.2003.00071.x.

Lagarkova MA, Koroleva EP, Kuprash DV, Boitchenko VE, Kashkarova UA, Nedospasov SA, Shebzukhov YV. Evaluation of humoral response to tumor antigens using recombinant expression-based serological mini-arrays (SMARTA). Immunol Lett. 2003. 85(1):71-4. doi: 10.1016/s0165-2478(02)00209-2.

Abe K, Yarovinsky FO, Murakami T, Shakhov AN, Tumanov AV, Ito D, Drutskaya LN, Pfeffer K, Kuprash DV, Komschlies KL, Nedospasov SA. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood. 2003. 101(4):1477-83. doi: 10.1182/blood.V101.4.1477.

Tumanov AV, Kuprash DV, Nedospasov SA. The role of lymphotoxin in development and maintenance of secondary lymphoid tissues. Cytokine Growth Factor Rev. 2003. 14(3-4):275-88. doi: 10.1016/s1359-6101(03)00026-1.

2002

Kuprash DV, Alimzhanov MB, Tumanov AV, Grivennikov SI, Shakhov AN, Drutskaya LN, Marino MW, Turetskaya RL, Anderson AO, Rajewsky K, Pfeffer K, Nedospasov SA. Redundancy in tumor necrosis factor (TNF) and lymphotoxin (LT) signaling in vivo: mice with inactivation of the entire TNF/LT locus versus single-knockout mice. Mol Cell Biol. 2002. 22(24):8626-34. doi: 10.1128/MCB.22.24.8626-8634.2002.

Kuprash DV, Boitchenko VE, Yarovinsky FO, Rice NR, Nordheim A, Rühlmann A, Nedospasov SA. Cyclosporin A blocks the expression of lymphotoxin alpha, but not lymphotoxin beta, in human peripheral blood mononuclear cells. Blood. 2002. 100(5):1721-7. PMID: 12176893

Tumanov A, Kuprash D, Lagarkova M, Grivennikov S, Abe K, Shakhov A, Drutskaya L, Stewart C, Chervonsky A, Nedospasov S. Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity. 2002. 17(3):239-50. doi: 10.1016/s1074-7613(02)00397-7.

2001

Kuimov AN, Kuprash DV, Petrov VN, Vdovichenko KK, Scanlan MJ, Jongeneel CV, Lagarkova MA, Nedospasov SA. Cloning and characterization of TNKL, a member of tankyrase gene family. Genes Immun. 2001. 2(1):52-5. doi: 10.1038/sj.gene.6363722.

2000

Eskdale J, Turestkaya RL, Armstrong C, Kuprash DV, Nedospasov SA, Gallagher G. A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a. Genes Immun. 2000. 1(3):228-30. doi: 10.1038/sj.gene.6363663.

Drize NI, Drutskaya MS, Gerasimova LP, Manakova TE, Chertkov IL, Turetskaya RL, Kuprash DV, Nedospasov SA. Changes in the hemopoietic system of mice deficient for tumor necrosis factor or lymphotoxin-alpha. Bull Exp Biol Med. 2000. 130(7):676-8. doi: 10.1007/BF02682103.

1999

Kuprash DV, Alimzhanov MB, Tumanov AV, Anderson AO, Pfeffer K, Nedospasov SA. TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. J Immunol. 1999. 163(12):6575-80. PMID: 10586051

Kuprash DV, Udalova IA, Turetskaya RL, Kwiatkowski D, Rice NR, Nedospasov SA. Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J Immunol. 1999. 162(7):4045-52. PMID: 10201927

1997

Alimzhanov MB, Kuprash DV, Kosco-Vilbois MH, Luz A, Turetskaya RL, Tarakhovsky A, Rajewsky K, Nedospasov SA, Pfeffer K. Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A. 1997. 94(17):9302-7. doi: 10.1073/pnas.94.17.9302.

1996

Kuprash DV, Osipovich OA, Pokholok DK, Alimzhanov MB, Biragyn A, Turetskaya RL, Nedospasov SA. Functional analysis of the lymphotoxin-beta promoter. Sequence requirements for PMA activation. J Immunol. 1996. 156(7):2465-72. PMID: 8786306